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Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-066-005Place Order
50 ug300.00APT001-066-050Place Order
1 mg3,500.00APT001-066-mgPlace Order
 Download Datasheet in PDF
Product NamesCD40L
DescriptionRecombinant protein of active form without-tag.
Molecular Mass16183.38 Daltons
SourceE.coli
Sizes5ug, 50ug, 1000ug
Purity>98%
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundSoluble CD40 ligand/ soluble CD154: CD40L inducing ligand is a protein that belongs to the tumor necrosis factor (TNF) ligand family which functions as prominent mediators of immune regulation and the inflammatory response. CD40 binds CD40L expressed on Antigen presenting cells (APC) (1). CD40-CD40L pathway functions in T cell response, IL-12 production and regulates B cell functions (2).
References1. Sch?nbeck U, Libby P. 2001. "The CD40/CD154 receptor/ligand dyad". Cell. Mol. Life Sci. 58 (1): 4C43.Zheng, S.-J. et.al: Critical roles of TRAIL in hepatic cell death and hepatic inflammation. J. Clin. Invest. 113: 58-64, 2004. 2. Laman JD, Claassen E, Noelle RJ. 1996. Functions of CD40 and its ligand, gp39 (CD40L). Crit Rev Immunol. 1996;16(1):59-108.


 
 

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