Advanced Protein Technology Company Brochure  
   

 
Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-068-005Place Order
50 ug300.00APT001-068-050Place Order
1mg3,500.00APT001-068-mgPlace Order
 Download Datasheet in PDF
Product NamemBMP-4
DescriptionRecombinant protein of active form without-tag.
Molecular Mass13285.19 Daltons
SourceE.coli
Sizes5ug, 50ug, 1000ug
Purity>98%
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundBMP-4 is a member of the bone morphogenetic protein family that is part of the transforming growth factorbeta superfamily. BMP-4 plays an important role in the onset of endochondral bone formation and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva (1). BMP-4 acts as a novel, noncytotoxic therapeutic effector that is used to prevent growth and recurrence of glioblastomas (2). Mouse BMP4 shares 98% homology with human BMP-4.
References1. Kan, L., et.al. 2004. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Path. 165: 1107-1115, 2004. 2. Piccirillo, S. G. M. et.al. 2006. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444: 761-765, 2006.


 
 

  • Refolding Services
  • rScAb Production
  • Periplasmic Protein Expression
  • Custom Cleavaged Protein

Contact us | About us | Log In | Place Order | Terms & Privacy
©2016 - Advanced Protein Technology