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Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-041-005Place Order
50 ug300.00APT001-041-050Place Order
1 mg3,500.00APT001-041-mgPlace Order
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Product NameTNF-b
DescriptionRecombinant protein of active form without-tag.
Molecular Mass18791.46 Daltons
SourceE.coli
Sizes5ug, 50ug, 1000ug
Purity>98%
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundTNF- is a member of the tumor necrosis factor cytokine family that is primarily expressed on lymphocytes that control lipid metabolism. TNF- is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. TNF- acts as a novel therapeutic route for the treatment of dyslipidemia (1). The presence of TNF- accelerates the initiation of immune responses and protects the host from larger viral challenges (2).
References1. Lo, J. C. et.al: Lymphotoxin beta receptor-dependent control of lipid homeostasis. Science 316: 285-288, 2007. 2. Lund, F. E. et.al: Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immun. 169: 5236-5243, 2002.


 
 

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