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Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-040-005Place Order
50 ug300.00APT001-040-050Place Order
1 mg3,500.00APT001-040-mgPlace Order
 Download Datasheet in PDF
Product NameTNF-a
DescriptionRecombinant protein of active form without-tag.
Molecular Mass17482.93 Daltons
Sizes5ug, 50ug, 1000ug
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundTumor Necrosis Factor-Alpha: TNF- is a cytokine that belongs to the group of cytokines which function as prominent mediators of acute phase reaction and systemic inflammation. TNF- binds TNF R receptors which activates NF-B , MAPK pathway and induction of death signaling(1). TNF- functions to regulate immune response, mediate general inflammation, induce fever, activate leukocyte recruitment and upregulate HLA complex expression (2).
References1. Wajant H, Pfizenmaier K, Scheurich P . 2003. "Tumor necrosis factor signaling". Cell Death Differ. 10 (1): 45C65. 2. Heribert Schunkert and Gnter A. J. Riegger. 2000 Apoptosis in cardiac biology. Kluwer Academic Publishers- Dordrecht/Boston/London


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