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Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-073-005Place Order
50 ug300.00APT001-073-050Place Order
1 mg3,500.00APT001-073-mgPlace Order
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Product NameOsteoprotegerin
DescriptionRecombinant protein of active form without-tag.
Molecular Mass19841.47 Daltons
SourceE.coli
Sizes5ug, 50ug, 1000ug
Purity>98%
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundOsteoprotegerin: OPG is a cytokine receptor that belongs to the tumor necrosis factor (TNF) ligand family which functions as prominent mediators of immune regulation and the inflammatory response. OPG binds RANKL which functions to inhibit NF-B signaling; this acts to decrease differentiation, cell survival and immunity (1). OPG inhibits osteoclast production and differentiation and this serves to reduce bone reabsorption (2).
References1. Krakauer T (2008). "Nuclear factor-kappaB: fine-tuning a central integrator of diverse biologic stimuli". Int. Rev. Immunol. 27 (5): 286C92. 2. Jane E. Aubin et al. 2000. Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption. Medscape General Medicine. 2000;2(2)


 
 

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