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Product Datasheet
SizePriceCatalog #
5 ug99.00APT001-046-005Place Order
50 ug300.00APT001-046-050Place Order
1 mg3,500.00APT001-046-mgPlace Order
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Product NameIL-18
DescriptionRecombinant protein of active form without-tag.
Molecular Mass18346.95 Daltons
SourceE.coli
Sizes5ug, 50ug, 1000ug
Purity>98%
Endotoxin LevelLess than 0.1 ng/ug (IEU/ug) of protein as determined by the LAL method.
FormulationRecombinant protein stored in 1 X PBS, 10% glycerol.
Storage and StabilityStored at below -20C. It is stable at 4C between 2-7 days. For long term storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Purification SystemPurified by chromatographic techniques at least two methods.
Purity Purification
Country of OriginCANADA
UsageCell culture
BackgroundInterleukin 18: IL-18 is a cytokine that belongs to the IL-1 super family which function in immune response. IL-18 binds IL-18 receptor inducing cell-mediated immunity together with IL-12 during microbial infections (1). IL-18 can release Inferferon or type 2 interferon after stimulation of NK cells and certain T cells (2). IL-18 is also produced during chronic inflammation, various cancers and autoimmune diseases (3).
References1. Guifang Cai et al. 2000. Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to Toxoplasma gondii. Infect Immun. 2000 December; 68(12): 6932C6938. 2. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature 378 (6552): 88C91 3. Gracie JA, Robertson SE, McInnes IB. 2003. Interleukin-18. J Leukoc Biol. 2003 Feb;73(2):213-24


 
 

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